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The overexpression of LCN 2 leads to resistance to 5-FU in CRC cell lines in vitro and in vivo by decreasing intracellular iron levels and stimulating the expression of GPX4 and SLC7A11 ( Lymphoid-specific helicase (LSH) is involved in ferroptosis and is a potential therapeutic target in cancer because of its crucial role in ferroptosis

We demonstrate this by example: Figure 4 shows a comparison of the glucose-GSH profiles of 4 individuals (ages greater than 40)

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